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首页> 外文OA文献 >Normobaric hypoxic conditioning to maximise weight-loss and ameliorate cardio-metabolic health in obese populations: A systematic review.
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Normobaric hypoxic conditioning to maximise weight-loss and ameliorate cardio-metabolic health in obese populations: A systematic review.

机译：常压低氧调理，以最大限度地减肥和改善肥胖人群的心脏代谢健康：系统评价。

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Normobaric hypoxic conditioning (HC) denotes exposure to hypoxia at rest (passive) or combined with exercise (active). HC has been applied acutely (single exposure) and chronically (repeated exposure) to obese populations for managing/increasing cardio-metabolic health and weight loss. Cardio-metabolic health and weight loss responses of obese populations in response to passive and active HC are unclear. A systematic search for articles published between 2000-2017 was carried out. Studies investigating the effects of HC for improving cardio-metabolic health and weight loss of obese populations were included. Studies investigated passive (n = 7; 5 animal, 2 humans), active (n = 4; all humans) and a combination of (n = 4; 3 animal, 1 human) HC to an inspired oxygen fraction between 4.8-15.0%, during a single session and daily sessions per week, lasting between 5 days and 8 months. Passive HC could reduce insulin concentrations (-37-22%) and increase energy expenditure (+12-16). Active HC may reduce body weight (-4-2%) and blood pressure (-8-3%). Inconclusive findings exist in determining the impact of acute and chronic HC on markers of triglycerides, cholesterol levels and fitness capacity. Studies that included animal models involved exposure to severe levels of hypoxia (inspired oxygen fraction of 5.0%; simulated altitude >10,000 m) that are not suitable for human populations. HC demonstrated positive findings in relation to insulin and energy expenditure, and body weight and blood pressure, for improving the cardio-metabolic health and body weight management of obese populations. Responses of plasma biomarkers to passive and active HC in humans is warranted.
机译：常压低氧条件（HC）表示在休息（被动）或与运动（主动）相结合时接受低氧。 HC已被急性（单次暴露）和长期（反复暴露）应用于肥胖人群，以控制/增加心脏代谢健康和减轻体重。肥胖人群对被动和主动HC的心血管代谢健康和体重减轻反应尚不清楚。系统地搜索了2000-2017年之间发表的文章。包括研究HC对改善肥胖人群心脏代谢健康和减轻体重的影响的研究。研究调查了被动（n = 7; 5动物，2个人），主动（n = 4;所有人类）和（n = 4; 3动物，1人类）HC的组合，吸入的氧气分数在4.8-15.0％之间，每周进行一次，每天一次，持续5天到8个月。被动HC可以降低胰岛素浓度（-37-22％）并增加能量消耗（+ 12-16）。活跃的HC可减轻体重（-4-2％）和血压（-8-3％）。在确定急性和慢性HC对甘油三酸酯，胆固醇水平和适应能力指标的影响方面尚无定论。包括动物模型在内的研究均涉及不适合人类居住的严重低氧水平（吸入氧分数为5.0％；模拟高度> 10,000 m）。 HC显示出与胰岛素和能量消耗以及体重和血压有关的积极发现，可改善肥胖人群的心脏代谢健康和体重管理。血浆生物标志物对人类被动和主动HC的反应是有保证的。

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